Invited Lectures and Presentations (1980-1999)


  1. A new technique for the cytogenetic analysis of cells from single hemopoietic colonies of bone marrow or peripheral blood origin. Presented at the American Society of Human Genetics Annual Meeting, New York, USA, September 25th, 1980.

  2. A reliable method for the cytogenetic analysis of individual hemopoietic colonies and its potential applications. Presented to the Department of Genetics, University of Gothenburg, Sweden, August 21st,1981.

  3. Chromosomes as in-vitro markers in CML. Presented at the Cancer Control Agency of British Columbia, Vancouver, B.C. June 8th, 1982.

  4. Normal stem cells in CML. Presented at the Cancer Control Agency of British Columbia, Vancouver, B.C., October 10th, 1983

  5. In-vitro cytogenetic studies in CML. Presented at Medical Genetics Rounds, The B.C. Children's Hospital, Vancouver, B.C., December 9th, 1983.

  6. In-vitro cytogenetic studies in CML. Presented at Medical Genetics Rounds, The Alberta Children's Hospital, Calgary, December 12th, 1983.

  7. In vitro cytogenetic studies in CML. Presented at the Fourth Conference on Human Tumor Cloning, Tucson, Arizona, USA, January 8th, 1984.

  8. Stem cell concepts in tumor cytogenetics. Presented at the Canadian Society of Laboratory Technologists, National Congress, Vancouver, B.C., June 18th, 1984.

  9. Cytogenetic findings in Turner Syndrome. Presented at Medical Grand Rounds, The Hospital for Sick Children, Toronto, Ontario, August 22nd, 1984.

  10. Stem cell concepts and tumor cytogenetics - In vitro studies in CML. Presented at Genetics Rounds, The Hospital for Sick Children, Toronto, Ontario, October 24th, 1984.

  11. Prognostic value of cytogenetic changes in malignancies. Presented to the Canadian College of Medical Geneticists Annual Meeting, Banff, Alberta, February 8th, 1985.

  12. Tumor cytogenetics and stem cell concepts - In vitro studies in CML. Presented at the Lady Davis Institute, The Montreal Jewish General Hospital, Montreal, Quebec, March 29th, 1985.

  13. Normal stem cells in CML. Presented at the McGill Cancer Center, Montreal, Quebec, March 29th, 1985.

  14. Chromosome of solid tumors. Presented to the Division of Cytogenetics, The Toronto Institute of Medical Technology, Toronto, Ontario, April 12th, 1985.

  15. Prognostic value of chromosomal changes in hematological malignancies. Presented at Cytogenetics Rounds, The Toronto General Hospital, Toronto, Ontario, May 2nd, 1985.

  16. Chromosomal changes in malignant disease. Presented at Immunology Rounds, The Hospital for Sick Children, Toronto, Ontario, May 2nd, 1985.

  17. Prognostic value of karyotype in childhood ALL. Presented at Hematology/Oncology Rounds, The Hospital for Sick Children, Toronto, Ontario, June 6th, 1985.

  18. Normal hemopoietic stem cells in Philadelphia positive CML. Presented at the St. Jude Children's Research Hospital, Memphis, Tennessee, USA, June 16th, 1985.

  19. Deletion in the short arm of chromosome 9 in childhood acute lymphoblastic leukemia (ALL) without lymphomatous features. Presented at the Annual Meeting of the Genetics Society of Canada, London, Ontario, June 27th, 1985.

  20. Chromosome in cancer. Implications from studies in childhood leukemia. Presented at the University Area Oncology Rounds, The Hospital for Sick Children, Toronto, Ontario, November 15th, 1985.

  21. A new oncogene in T-cell neoplasia? Presented at Hematology Rounds, The Hospital for Sick Children, Toronto, Ontario, November 28th, 1985.

  22. Chromosome changes in cancer. Presented at the Pathology Lecture Series, Women's College Hospital, Toronto, Ontario, October 21st,1985.

  23. Cytogenetics in Haematology/Oncology. Presented at the Sixth Haematology Basic Seminar, Toronto General Hospital, Toronto, Ontario, March 5th, 1986.

  24. Leukemia cytogenetics: Pathogenesis, prognosis and the HSC experience. Presented at Genetics Rounds, The Hospital for Sick Children, Toronto, Ontario, March 29th, 1986.

  25. Translocation t(10;14) in T-cell neoplasia. Presented to the Department of Cytogenetics and Immunology, The Royal Marsden Hospital, London, England, April 17th, 1986.

  26. A putative oncogene at chromosomal band 10q24. Presented at the Great Lakes Chromosome Conference, Toronto, Ontario, May 21st, 1986.

  27. Molecular dissection of the 10;14 translocation in T-cell neoplasia. Presented at the Annual Meeting of the Clinical Research Society of Toronto, March 26th, 1988.

  28. Cytogenetic studies in hematological malignancies. Presented to the Genetics Department, North York General Hospital, Toronto, Ontario, March 27, 1986.

  29. Leukemia cytogenetics: Implications of pathogenesis and prognosis. Presented at the Manitoba Institute of Cell Biology, Winnipeg, Manitoba, April 3rd, 1986.

  30. Chromosome abnormalities in T-cell neoplasia. Presented at Immunology Rounds, The Hospital for Sick Children, Toronto, Ontario, April 9th, 1986.

  31. Lymphoma Cytogenetics. Presented at Hematology Rounds, The Wellesley Hospital, Toronto, Ontario, February 13th, 1987.

  32. Leukemia Cytogenetics. Presented at Leukemia Rounds, The Princess Margaret Hospital, Toronto, Ontario, March 30th, 1987.

  33. Cytogenetics in CML. Presented at Hematology Rounds, The Toronto Western Hospital, Toronto, Ontario, April 13th, 1987.

  34. Cytogenetics in Hematological Malignancy. Presented at Medical Oncology Rounds, The Bayview Clinic, Sunnybrook Medical Centre, Toronto, Ontario, April 15th, 1987.

  35. Molecular Biology of CML. Presented at City Wide Hematology Rounds, The Academy of Medicine, Toronto, Ontario, May 6th, 1987.

  36. Molecular Diagnosis in Oncology. Presented at the Annual Meeting of the Ontario Medical Association, The Ontario Hospitals Association, Toronto, Ontario, May 27th, 1987.

  37. Cancer Cytogenetics. Presented at Grand Medical Rounds, Toronto General Hospital, Toronto, Ontario, June 9th, 1987.

  38. Cancer Cytogenetics. Presented at the 1987 University of Toronto Pathology Reunion, The University of Toronto, June 4th, 1987.

  39. Chromosomes in Human Leukemia. Presented at the Canadian Society of Laboratory Technologists National Congress, Hamilton, Ontario, June 23rd, 1987.

  40. Cancer Cytogenetics. Presented at the University of Toronto, Department of Pathology, February 15th, 1988.

  41. Chromosomes of Solid Tumors. Presented to the Division of Cytogenetics, The Toronto Institute of Medical Technology, Toronto, Ontario, May 20th, 1988.

  42. Cytogenetics in Hematology/Oncology. Presented to the Ontario Society for Medical Technology Convention Annual Meeting, Toronto, Ontario, September 21st, 1988.

  43. Breakpoints occur within the delta-chain locus of the T-cell receptor gene in the t(10;14)(q24;q11) of T-cell neoplasia. Presented at the Annual Meeting of the American Society of Human Genetics, New Orleans, USA, October 12th, 1988.

  44. Cancer Cytogenetics: Service/Research. Presented at the Pathology Lecture Series, University of Toronto, April 24th, 1989.

  45. Chromosomes and cancer. Presented to the Department of Pathology, Kingston General Hospital, Kingston, Ontario, May 2nd, 1989.

  46. Location of breakpoints in chromosome 22 in 33 patients with unusual Philadelphia chromosomes. Presented at the Great Lakes Conference, Toronto, Ontario, May 26th, 1989.

  47. Molecular analysis of chromosomal translocations in leukemia. Presented at the Toronto General Hospital Research Day Symposium, Toronto, Ontario, May 30th, 1989.

  48. Cytogenetics in malignant lymphoma. Presented at Hematology Rounds, Toronto General Hospital, Toronto Ontario, June 23rd, 1989.

  49. Cloning and characterization of the putative oncogene involved in the t(10;14) of human T-cell neoplasia. Presented at Genetics Rounds, The Hospital for Sick Children, Toronto, Ontario, September 21st, 1989.

  50. Location of breakpoints within the major breakpoint cluster region (bcr) in 33 patients with bcr rearrangement-positive chronic myeloid leukemia (CML) with complex or absent Philadelphia chromosomes. Presented at the Annual Meeting of the American Society of Human Genetics, Baltimore, USA, November 14th, 1989.

  51. Molecular biology of complex Philadelphia chromosomes. Presented to the Toronto Leukemia Site Group Program, The Delta Chelsea Inn, Toronto, Ontario February 5th, 1990.

  52. Molecular Cytogenetics of leukemia. Presented at Genetics Rounds, McMaster University, Hamilton, Ontario, May 4th, 1990.

  53. Cloning of translocation breakpoints in human lymphoid neoplasia. Presented at the Clinical Biochemistry Department Seminar Series, Banting Institute, University of Toronto, May 9th, 1990.

  54. Recent advances in chronic myeloid leukemia. Presented at Grand Medical Rounds, Mount Sinai Hospital, Toronto, Ontario, June 13th, 1990.

  55. In search of new oncogenes. Presented at Hematology Rounds, Toronto General Hospital, Toronto, Ontario, June 22,nd 1990.

  56. The TCL3 oncogene is expressed in normal tissue and is dysregulated via recombinase mediated recombination in leukemic cells from patients with t(10;14) T-ALL. Presented at the Annual Meeting of the American Society of Hematology, Boston, USA, December 3rd, 1990.

  57. Solving the TCL3 riddle. Presented at the Great Lakes Chromosome Conference, Toronto, Ontario, May 24th, 1991.

  58. A new gene involved in human acute leukemia. Presented at the Terry Fox Cancer Research and Immunology Seminar Series, The Hospital For Sick Children, Toronto, Ontario, May 29th, 1991.

  59. A new human homeobox gene is deregulated in lymphoid neoplasias with the t(10;14)(q24;q11) translocation. Presented at the 2nd Eastern Canadian Conference on Development and Cancer, Montreal, Quebec, September 23rd, 1991.

  60. HOX11, a new homeobox gene is deregulated in lymphoid neoplasias with the t(10;14)(q24;q11) translocation. Presented at the 8th International Congress of Human Genetics, Washington, DC, USA, October 8th, 1991.

  61. Cytogenetics in Hematology/Oncology. Presented at the Basic Science Seminar for trainees in Hematology, Toronto General Hospital, Toronto, Ontario, November 27th, 1991.

  62. Expression of HOX11, the oncogene deregulated in t(10;14) T-ALL, causes transformation of N1H 3T3 cells and facilitates growth of human leukemic cells in immune-deficient mice. Presented at the 1991 Annual Meeting of the American Society of Hematology, Denver, Colorado, USA, December 9th, 1991.

  63. Characterization of HOX11: a new gene involved in human cancer. Presented at the 1992 Annual Meeting of the Clinical Research Society of Toronto, Toronto, Ontario, April 11th, 1992.

  64. Molecular Pathology and the Search For New Genes. Presented at Grand Medical Rounds, Sunnybrook Health Science Center, Toronto, Ontario, May 19th, 1992.

  65. Gene Transfer Into Hematopoietic Stem Cells. Presented at Citywide Hematology Rounds, Toronto General Hospital, Toronto, Ontario, May 12, 1993.

  66. Gene Transfer Into Pluripotent Hematopoietic Stem Cells. Presented at McGill Cancer Center, McIntyre Medical Sciences Building, Montreal, Quebec, May 28, 1993.

  67. Gene Transfer Into Pluripotent Hematopoietic Stem Cells. Presented at the Immunology Seminar Series, The Hospital For Sick Children, Toronto, Ontario, June 16th, 1993.

  68. The Cancer Cytogenetics and Molecular Oncology Program. Indications for Testing. Presented to the Department of Hematology/Oncology Nursing Staff, The Hospital for Sick Children, Toronto, Ontario, June 15, 1993.

  69. Gene Transfer into Pluripotent Hematopoietic Stem Cells. Presented to the Immunology Sciences Research Group, Foothills Hospital, Calgary, Alberta, June 28th, 1993.

  70. Cytogenetics and Molecular Genetics in the Pathophysiology of Myelodysplastic Syndromes. Presented at the Annual Meeting of the Canadian Association of Pathologist, Banff, Alberta, June 28th, 1993.

  71. From Bedside to Bench; Follow-up of Routine Diagnostic Testing in Lymphoid Neoplasia Gives New Insights into Cancer Biology. Leica Scientific Award presentation. Presented at the Annual Meeting of the Canadian Association of Pathologist, Banff, Alberta, June 29th, 1993.

  72. Gene Transfer into Hematopoietic Stem Cells. Presented at Progress in Pathology Rounds, Women's College Hospital, Toronto, September 7th, 1993.

  73. Gene Transfer into Hematopoietic Stem Cells. Presented at Genetics Rounds, The Hospital for Sick Children, Toronto, September 30th, 1993.

  74. Long-term engraftment of genetically modified stem cells without marrow ablation. Presented at the Second International Conference on Gene Therapy of Cancer, San Diego, California, USA, November 19th, 1993.

  75. In vitro activation of hematopoietic progenitors with extensive capacities for in vivo proliferation. Presented at the 1994 Academic Half-Day in Hematology, Sunnybrook Health Sciences Center, January 29th, 1994.

  76. Stem cell marking in multiple myeloma. Presented to Inex Pharmaceuticals, Vancouver, BC, March 10th, 1994.

  77. Hematopoietic stem cell gene transfer. Presented at Perinatology Research Rounds, The Hospital for Sick Children, Toronto, March 21, 1994.

  78. Gene Transfer into bone marrow. Presented to the Canadian Society for Transfusion Medicine, Annual General Meeting, Montreal, May 15th, 1994.

  79. Gene therapy. Presented at the Second Annual Member Profile Marathon of the Toronto Biotechnology Initiative, Toronto, June 16th, 1994.

  80. Recent advances in characterizing genes involved in chromosome translocations in cancer: An update. Presented at the Canadian Society of Laboratory Technologists, Vancouver, BC., June 1994.

  81. Recent advances in characterizing genes involved in chromosome translocations in cancer. Presented at Victoria General Hospital, July 13th, 1994.

  82. How bad genes can be made good. Presented to the Board of Directors of the Toronto Hospital, July 19th, 1994.

  83. Gene Therapy. Presented at the Pathology Summer Student Series, The Toronto Hospital, July 27, 1994.

  84. Gene Therapy in Canada. Presented at Bionet '94 Conference, Vancouver, B.C., October 13th, 1994.

  85. Canada's First Gene Therapy Trial. Presented to the Biology Department, University of Victoria, B.C., November 3rd, 1994.

  86. Gene transfer into canine hematopoietic stem cells and reconstitution without ablation. Presented at the Gene Therapy Symposium. Center Jacques Cartier and Fondation Marcel Mérieux, Annecy, France, December 1, 1994.

  87. Gene transfer into hematopoietic stem cells. Presented at Somatix Therapy Corporation, Alameda, California, December 15, 1994.

  88. Gene transfer into hematopoietic stem cells and adoptive transfer in the absence of myeloablation. Presented at the Septiémes entretiens Jacques Cartier Colloque sur la thérapie génique, Annecy, France, December 1, 1994.

  89. Gene transfer into hematopoietic stem cells. Presented at the Séminaires de L'Institut d'Hématologie Hôpital Saint-Louis, Paris, France, January 30, 1995.

  90. Blood cells: vehicles for gene therapy. Presented at the Division of Cancer Biology Research Seminar Series, Reichmann Research Building, Summybrook Health Science Centre, Toronto, February 22, 1995.

  91. Update of the Toronto Hospital's Gene Therapy Trial. Presented at Genetics Rounds, The Hospital For Sick Children, Toronto, May 15th, 1995.

  92. Molecular Cancer Cytogenetics - Recent Advances. Presented at the 25th Annual Meeting of the American Association of Cytotechnologists, San Antonio, Texas, USA, June 2nd, 1995.

  93. Adoptive transfer of genetically modified hematopoietic stem cells. Presented at the June 1995 Toronto Symposium: Gene Therapy in Canada. June 27, 1995.

  94. Gene transfer into marrow derived hematopoietic stem cells. Presented at the OECD Workshop on Gene Delivery Systems, Ottawa, Canada, June 27, 1995.

  95. Prelude to gene therapy: stem cell marking in multiple myeloma - a clinical trial. Presented at City Wide Oncology Rounds, Toronto, Ontario, September 17, 1995.

  96. Ex-vivo activation of hematopoietic stem cells facilitates transduction and adoptive transfer. Presented at the First Conference on Stem Cell Gene Therapy: Biology and Technology, Chevy Chase, Maryland, USA, September 28, 1995.

  97. An update of The Toronto Hospital clinical gene transfer protocol. Presented at Pathology Rounds, Queen's University, Kingston, Ontario, November 21, 1995.

  98. Gene therapy- Part 1. Presented at Oncology Grand Rounds, Sunnybrook Health Science Centre, Toronto, January 24, 1996.

  99. Blood cells for gene therapy. Presented at the Eye Research Institute of Canada, The Toronto Hospital, Western Division, January 26, 1996.

  100. Adoptive transfer of long-term marrow culture cells. Presented at the 1996 Keystone Symposia on Gene Therapy for Hematopoietic Stem Cells in Genetic Disease and Cancer. Taos, New Mexico, USA, February 5, 1996.

  101. Use of long term bone marrow cultures for transduction of hematopoietic stem cells:in vivo studies. Presented at Somatix Therapy Corporation. Alameda, California, USA, March 1, 1996.

  102. Early results from a clinical trial of stem cell marking in multiple myeloma. Presented at the 1996 European Working Group on Gene Therapy Workshop of the Annual Meeting of the European Hematology Association. Paris, France, May 29th, 1996.

  103. Gene transfer into hematopoietic stem cells. Presented at Hematology Rounds, University of British Columbia and Terry Fox Laboratory, Vancouver, B.C., June 20th, 1996.

  104. Gene transfer studies in dogs. Presented at the NIH Symposium on In-utero Stem Cell Transplantation and Gene Therapy. Reno, Nevada, USA September 11, 1996.

  105. In-utero gene transfer in a canine model. Presented at the NIH Symposium on In-utero Stem Cell Transplantation and Gene Therapy. Reno, Nevada, USA, September 10th, 1996.

  106. An overview of Gene Therapy. Presented at the Gene Therapy Symposium of the Annual Meeting of the Royal College of Physicians and Surgeons of Canada. Halifax, Nova Scotia, September 28, 1996.

  107. Gene marking of cells using long term marrow culture. Presented at the AACR Second Annual Meeting of the American Society of Blood and Marrow Transplantation. San Diego, California, USA, October 2nd, 1996.

  108. Activation of hematopoietic stem cells for gene therapy. Presented at Pfizer's Stem Cell Hematopoiesis and Gene Therapy Symposium. La Jolla, California, USA, November 6, 1996.

  109. Gene therapy. Presented at Nesbitt Burns Biotechnology Conference, Toronto, Ontario, November 26, 1996.

  110. Blood progenitor cells for gene therapy. Presented at the Boden Conference on Gene Therapy. Australia, February 4-7, 1997.

  111. Human gene therapy: progress and prognosis. Presented at the Boden Conference on Gene Therapy. Australia, February 4-7, 1997.

  112. In vitro systems for hematopoietic stem cell gene transfer. Presented at the Symposium on Hematopoietic Stem Cells: Biology, Lymphopoiesis and Transplantation of the 1997 Joint Annual Meeting of the American Association of Immunologists. San Francisco, California, USA, February 21-26, 1997.

  113. Long-term marrow cultures activate hematopoietic stem cells for gene transfer. Presented at the 23rd Annual Meeting of the European Group for Blood and Marrow Transplantation. Aix-les-Bains, France, March 23-27, 1997.

  114. Overview of gene therapy. Presented at the National Research Council of Canada, Biotechnology Institute. Montreal, Quebec, May 8, 1997.

  115. Optimization of transfection methods for gene transfer. Presented at the Third Annual Meeting of the International Society of Hematotherapy and Graft Engineering. Bordeaux, France. May 31, 1997 to June 3, 1997.

  116. Gene transfer into hematopoietic stem cells. Presented at the Molecular Biology of Hematopoiesis Symposium. Hamburg, Germany, July 3-6, 1997.

  117. Overview of Gene therapy. Presented at the Canadian College of Medical Geneticists Scientific Symposium, Victoria, B.C. September 1997.

  118. Experience with stromal-based system for human and canine gene transfer. Presented at the 2nd Conference on Stem Cell Gene Therapy. Orcas Island, Washington. May 31, 1998.

  119. Pre-clinical and clinical studies of hematopoietic stem cell gene transfer. Presented at the 25th Anniversary of the Dept. of Medical Genetics, University of British Columbia, Vancouver, B.C. June 6, 1998.

  120. HOX11, a homeodomain-containitranscription factor dysregulated in the t(10;14) translocation of lymphoid malignancy, induces B-lymphoid malignancies in IgHm-HOX11 transgenic mice. Presented at the 27th Annual Meeting of International Society for Experimental Hematology, Vancouver, B.C. August 1-5, 1998.

  121. Gene therapy, past and future. Presented at the 3rd Canadian Symposium on Gene Therapy. Montreal, Quebec, June 26-28, 1998.

  122. Genetic modification of hematopoietic stem cells. Presented at the Fondazione Matarelli Educational Symposium: New Frontiers in Oncology and Hematology. Milan, Italy; November 20-21, 1998.

  123. Gene marking in malignancies. Presented at the Advances in Gene Therapy of Cancer ,1999 Eurocancer Annual Meeting. Paris, France; June 4, 1999.

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